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Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

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Science  27 Jul 2012:
Vol. 337, Issue 6093, pp. 477-481
DOI: 10.1126/science.1218831

Article Information

vol. 337 no. 6093 477-481

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 6, 2012
  • Accepted for publication June 7, 2012
  • .

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Author Information

  1. Hiutung Chu1,
  2. Marzena Pazgier2,
  3. Grace Jung3,
  4. Sean-Paul Nuccio1,
  5. Patricia A. Castillo1,
  6. Maarten F. de Jong1,
  7. Maria G. Winter1,
  8. Sebastian E. Winter1,
  9. Jan Wehkamp1,*,
  10. Bo Shen4,
  11. Nita H. Salzman5,
  12. Mark A. Underwood6,
  13. Renee M. Tsolis1,
  14. Glenn M. Young7,
  15. Wuyuan Lu2,,
  16. Robert I. Lehrer3,,
  17. Andreas J. Bäumler1,,
  18. Charles L. Bevins1,
  1. 1Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.
  2. 2Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  3. 3Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
  4. 4Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
  5. 5Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  6. 6Department of Pediatrics, School of Medicine, University of California, Davis, CA 95616, USA.
  7. 7Department of Food Science and Technology, University of California, Davis, CA 95616, USA.
  1. To whom correspondence should be addressed. E-mail: clbevins{at}ucdavis.edu
  1. These authors contributed equally to this work.

  • * Present address: Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany.

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