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Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels

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Science  10 Aug 2012:
Vol. 337, Issue 6095, pp. 738-742
DOI: 10.1126/science.1217815

Article Information

vol. 337 no. 6095 738-742

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History: 
  • Received for publication December 13, 2011
  • Accepted for publication June 14, 2012
  • .

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Author Information

  1. Netanel Korin1,
  2. Mathumai Kanapathipillai1,
  3. Benjamin D. Matthews2,3,
  4. Marilena Crescente4,5,
  5. Alexander Brill4,5,
  6. Tadanori Mammoto2,
  7. Kaustabh Ghosh2,
  8. Samuel Jurek2,
  9. Sidi A. Bencherif1,6,
  10. Deen Bhatta6,
  11. Ahmet U. Coskun7,
  12. Charles L. Feldman8,
  13. Denisa D. Wagner4,5,
  14. Donald E. Ingber1,2,6,*
  1. 1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
  2. 2Vascular Biology Program, Departments of Pathology and Surgery, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Department of Medicine, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Immune Disease Institute, Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Boston, MA 02115, USA.
  5. 5Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
  6. 6School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  7. 7Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115, USA.
  8. 8Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
  1. *To whom correspondence should be addressed. E-mail: don.ingber{at}wyss.harvard.edu

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