Research Article

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Science  17 Aug 2012:
Vol. 337, Issue 6096, pp. 816-821
DOI: 10.1126/science.1225829

Article Information

vol. 337 no. 6096 816-821

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History: 
  • Received for publication June 8, 2012
  • Accepted for publication June 20, 2012
  • .

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Author Information

  1. Martin Jinek1,2,*,
  2. Krzysztof Chylinski3,4,*,
  3. Ines Fonfara4,
  4. Michael Hauer2,,
  5. Jennifer A. Doudna1,2,5,6,,
  6. Emmanuelle Charpentier4,
  1. 1Howard Hughes Medical Institute (HHMI), University of California, Berkeley, CA 94720, USA.
  2. 2Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
  3. 3Max F. Perutz Laboratories (MFPL), University of Vienna, A-1030 Vienna, Austria.
  4. 4The Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, Department of Molecular Biology, Umeå University, S-90187 Umeå, Sweden.
  5. 5Department of Chemistry, University of California, Berkeley, CA 94720, USA.
  6. 6Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
  1. To whom correspondence should be addressed. E-mail: doudna{at}berkeley.edu (J.A.D.); emmanuelle.charpentier{at}mims.umu.se (E.C.)
  1. * These authors contributed equally to this work.

  • Present address: Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.

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