07 September 2012
Vol 337, Issue 6099

About The Cover

Cover image expansion

COVER Artist's conception of the complex network of relationships between disease and the human genome. Hundreds of diseases and traits (represented by colored dots) have been mapped to specific chromosomal positions in the genome. Most disease-associated genetic variants fall outside of protein-coding genes, instead affecting the genome's regulatory circuitry by modifying the DNA "switches" (some of which are depicted here as gray triangles, many others not shown) that control gene activity. See page 1190. Image: Rachael Ludwig and John Stamatoyannopoulos