Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses

Timothy W. Hand; Liliane M. Dos Santos; Nicolas Bouladoux; Michael J. Molloy; Antonio J. Pagán; Marion Pepper; Craig L. Maynard; Charles O. Elson; Yasmine Belkaid

doi:10.1126/science.1220961

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Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses

Timothy W. Hand¹,
Liliane M. Dos Santos¹,²,
Nicolas Bouladoux¹,
Michael J. Molloy¹,
Antonio J. Pagán³,
Marion Pepper³,⁴,
Craig L. Maynard⁵,
Charles O. Elson III⁶,
Yasmine Belkaid¹,*

¹Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
²Laboratory of Gnotobiology and Immunology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.
³Microbiology, Immunology and Cancer Biology Program, University of Minnesota, Minneapolis, MN 55455, USA.
⁴Department of Immunology, University of Washington, Seattle, WA 98195, USA.
⁵Department of Pathology, University of Alabama–Birmingham, Birmingham, AL 35294, USA.
⁶Mucosal HIV and Immunobiology Center, University of Alabama–Birmingham, Birmingham, AL 35294, USA.

↵*To whom correspondence should be addressed. E-mail: ybelkaid{at}niaid.nih.gov

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Science 21 Sep 2012:
Vol. 337, Issue 6101, pp. 1553-1556
DOI: 10.1126/science.1220961

Timothy W. Hand

1Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Liliane M. Dos Santos

1Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

2Laboratory of Gnotobiology and Immunology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.

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Nicolas Bouladoux

1Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Michael J. Molloy

1Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Antonio J. Pagán

3Microbiology, Immunology and Cancer Biology Program, University of Minnesota, Minneapolis, MN 55455, USA.

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Marion Pepper

3Microbiology, Immunology and Cancer Biology Program, University of Minnesota, Minneapolis, MN 55455, USA.

4Department of Immunology, University of Washington, Seattle, WA 98195, USA.

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Craig L. Maynard

5Department of Pathology, University of Alabama–Birmingham, Birmingham, AL 35294, USA.

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Charles O. Elson III

6Mucosal HIV and Immunobiology Center, University of Alabama–Birmingham, Birmingham, AL 35294, USA.

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Yasmine Belkaid

1Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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For correspondence: ybelkaid@niaid.nih.gov

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