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Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

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Science  11 Jan 2013:
Vol. 339, Issue 6116, pp. 211-214
DOI: 10.1126/science.1227166

Article Information

vol. 339 no. 6116 211-214

PubMed: 
Print ISSN: 
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History: 
  • Received for publication July 9, 2012
  • Accepted for publication November 16, 2012

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Author Information

  1. Tadahiro Shimazu1,2,
  2. Matthew D. Hirschey1,2,
  3. John Newman1,2,
  4. Wenjuan He1,2,
  5. Kotaro Shirakawa1,2,
  6. Natacha Le Moan3,
  7. Carrie A. Grueter4,5,
  8. Hyungwook Lim1,2,
  9. Laura R. Saunders1,2,
  10. Robert D. Stevens6,
  11. Christopher B. Newgard6,
  12. Robert V. Farese Jr.2,4,5,
  13. Rafael de Cabo7,
  14. Scott Ulrich8,
  15. Katerina Akassoglou3,
  16. Eric Verdin1,2,*
  1. 1Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.
  2. 2Department of Medicine, University of California, San Francisco, CA 94143, USA.
  3. 3Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
  4. 4Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.
  5. 5Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.
  6. 6Sarah W. Stedman Nutrition and Metabolism Center, and Departments of Pharmacology and Cancer Biology and Medicine, Duke University Medical Center, Durham, NC 27704, USA.
  7. 7Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
  8. 8Department of Chemistry, Ithaca College, Ithaca, NY 14850, USA.
  1. *To whom correspondence should be addressed. E-mail: everdin{at}gladstone.ucsf.edu

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Article usage: December 2012 to July 2019

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