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Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

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Science  11 Jan 2013:
Vol. 339, Issue 6116, pp. 222-226
DOI: 10.1126/science.1226603

Article Information

vol. 339 no. 6116 222-226

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History: 
  • Received for publication June 26, 2012
  • Accepted for publication October 22, 2012

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Author Information

  1. Ng Shyh-Chang1,2,3,4,5,6,
  2. Jason W. Locasale5,6,*,
  3. Costas A. Lyssiotis5,6,
  4. Yuxiang Zheng5,6,
  5. Ren Yi Teo1,
  6. Sutheera Ratanasirintrawoot1,2,3,
  7. Jin Zhang1,2,3,
  8. Tamer Onder1,2,3,
  9. Juli J. Unternaehrer1,2,3,
  10. Hao Zhu1,2,3,
  11. John M. Asara5,
  12. George Q. Daley1,2,3,4,,
  13. Lewis C. Cantley5,6,
  1. 1Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  2. 2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  4. 4Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
  5. 5Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  6. 6Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  1. To whom correspondence should be addressed. E-mail: george.daley{at}childrens.harvard.edu (G.Q.D.); lewis_cantley{at}hms.harvard.edu (L.C.C.)
  • * Present address: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA.

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