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Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

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Science  18 Jan 2013:
Vol. 339, Issue 6117, pp. 307-310
DOI: 10.1126/science.1231434

Article Information

vol. 339 no. 6117 307-310

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History: 
  • Received for publication October 12, 2012
  • Accepted for publication November 30, 2012
  • .

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Author Information

  1. Pedro S. Coelho1,*,
  2. Eric M. Brustad2,*,
  3. Arvind Kannan1,
  4. Frances H. Arnold1,
  1. 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  2. 2Department of Chemistry and Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  1. To whom correspondence should be addressed. E-mail: frances{at}cheme.caltech.edu
  1. * These authors contributed equally to this work.

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