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A Strategy for Modulation of Enzymes in the Ubiquitin System

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Science  01 Feb 2013:
Vol. 339, Issue 6119, pp. 590-595
DOI: 10.1126/science.1230161

Article Information

vol. 339 no. 6119 590-595

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History: 
  • Received for publication September 13, 2012
  • Accepted for publication December 7, 2012
  • .

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Author Information

  1. Andreas Ernst1,
  2. George Avvakumov2,
  3. Jiefei Tong3,
  4. Yihui Fan4,
  5. Yanling Zhao4,
  6. Philipp Alberts3,
  7. Avinash Persaud3,5,
  8. John R. Walker2,
  9. Ana-Mirela Neculai1,
  10. Dante Neculai2,
  11. Andrew Vorobyov1,
  12. Pankaj Garg1,
  13. Linda Beatty1,
  14. Pak-Kei Chan6,
  15. Yu-Chi Juang7,
  16. Marie-Claude Landry7,
  17. Christina Yeh7,8,
  18. Elton Zeqiraj7,
  19. Konstantina Karamboulas1,
  20. Abdellah Allali-Hassani2,
  21. Masoud Vedadi2,
  22. Mike Tyers6,7,
  23. Jason Moffat1,8,9,10,
  24. Frank Sicheri7,8,
  25. Laurence Pelletier7,8,
  26. Daniel Durocher7,8,
  27. Brian Raught10,
  28. Daniela Rotin3,5,
  29. Jianhua Yang4,
  30. Michael F. Moran3,8,9,
  31. Sirano Dhe-Paganon2,11,
  32. Sachdev S. Sidhu1,8,9,10,*
  1. 1Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  2. 2Structural Genomics Consortium, MaRS Centre, 101 College Street, Suite 700, Toronto, Ontario M5G 1L7, Canada.
  3. 3Hospital for Sick Children, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
  4. 4Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
  5. 5Biochemistry Department, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
  6. 6Institut de Recherche en Immunologie et Cancérologie, Université de Montréal, Montreal, Quebec H3C 3J7, Canada.
  7. 7Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.
  8. 8Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  9. 9Banting and Best Department of Medical Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  10. 10Ontario Cancer Institute and McLaughlin Centre for Molecular Medicine, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
  11. 11Department of Physiology, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
  1. *To whom correspondence should be addressed. E-mail: sachdev.sidhu{at}utoronto.ca

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