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Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

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Science  08 Feb 2013:
Vol. 339, Issue 6120, pp. 711-715
DOI: 10.1126/science.1230624

Article Information

vol. 339 no. 6120 711-715

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History: 
  • Received for publication September 24, 2012
  • Accepted for publication November 16, 2012

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Author Information

  1. Michela Di Virgilio1,
  2. Elsa Callen3,*,
  3. Arito Yamane4,*,
  4. Wenzhu Zhang5,*,
  5. Mila Jankovic1,
  6. Alexander D. Gitlin1,
  7. Niklas Feldhahn1,
  8. Wolfgang Resch4,
  9. Thiago Y. Oliveira1,6,7,
  10. Brian T. Chait5,
  11. André Nussenzweig3,
  12. Rafael Casellas4,
  13. Davide F. Robbiani1,
  14. Michel C. Nussenzweig1,2,
  1. 1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  2. 2Howard Hughes Medical Institute (HHMI), The Rockefeller University, New York, NY 10065, USA.
  3. 3Laboratory of Genome Integrity and Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  4. 4Genomics and Immunity and National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NCI, NIH, Bethesda, MD 20892, USA.
  5. 5Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY 10065, USA.
  6. 6Department of Genetics, Faculty of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
  7. 7National Institute of Science and Technology for Stem Cells and Cell Therapy, Ribeirão Preto, Brazil.
  1. To whom correspondence should be addressed. E-mail: nussen{at}rockefeller.edu
  1. * These authors contributed equally to this work.

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