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Science  08 Feb 2013:
Vol. 339, Issue 6120, pp. 718
DOI: 10.1126/science.339.6120.718-a


A new carbon dioxide (CO2) sensor combines precise and reliable determination of dissolved CO2, with the performance benefits of Intelligent Sensor Management. The new InPro 5000i is a fully sterilizable and autoclavable in-line CO2 sensor. The sensor's membrane provides an excellent barrier against volatile organic acids, ensuring errorless measurement. The InPro 5000i's modular design makes maintenance and spare part replacement fast and convenient. The ideal housing for the sensor is the retractable InTrac 797 as its integrated flushing chamber allows easy sensor calibration and cleaning, even during a running fermentation. The InPro 5000i is the latest member of the Intelligent Sensor Management (ISM) family of sensors and transmitters. ISM is a digital platform for analytical measurement solutions. ISM's predictive diagnostic tools constantly monitor the InPro 5000i's "health" so that it can be easily determined if the sensor can be safely used for the next fermentation run.


Offering 24 high-volume (3.1 mL) wells in an industry standard 96-well plate footprint, the Krystal 24 provides a large surface area per well, enabling unmatched cell growth. Constructed in ultrapure grade polystyrene, Krystal 24 microplates are tissue-culture treated to ensure optimal cell growth and attachment. Precisely manufactured to ANSI/SLAS microplate dimensions, the microplates are fully compatible with all commercially available plate readers, robotic sample processors, and automated liquid handling systems. The plate edges and lids are designed to reduce evaporation, and the raised well rims reduce the risk of cross contamination. The unique Krystal 24 design also provides the convenience of direct measurements on bottom reading spectrophotometers and inverted microscopes. For sensitive fluorescence measurements, the black Krystal 24 plate provides the all-absorbing background needed to minimize background interference. The opaque white Krystal 24 plate maximizes reflectivity enabling even weakly emitting luminescence assays to be routinely undertaken.


The new Clonetics Fresh Human Pancreatic Islets possess a guaranteed quality with each batch tested for quantity (total IEQ), viability, purity, and sterility. They can be used in a variety of research areas including islet cell transplantation, insulin production, cell metabolism, immunosuppression, and other metabolic disorders. Some of the major challenges within diabetes research are the acquisition and availability of high-quality islet cells. Researchers now have easy access to islets to support research in long-term islet grafting survival, prevention of islet rejection, and prevention of adverse effects from immunosuppressive drugs.


The Seahorse XFe Extracellular Flux Analyzer measures the two major energy pathways of the cell—mitochondrial respiration and glycolysis—in a microplate, in real-time. The XFe Analyzer and stress test kits have standardized the measurements of mitochondrial dysfunction and glycolysis, enabling scientists to better understand the connection between physiological traits of cells with genomic and proteomic data. The XFe Analyzer and stress test kits are the gold standard platform for metabolic assays in neuroscience. The XFe Analyzer is able to identify mitochondrial dysfunction and subtle changes in neuronal cell metabolism before the development of observable neurodegeneration. The XFe Analyzer sets a universal standard for acquiring and reporting cell metabolism data. It enables cloud-based sharing of the elements and protocols of metabolic experiments, affording new users and experts the opportunity to collaborate and accelerate their research.


The Cool Cut specimen clamp maintains block temperature for more consistent, better quality sections. Paraffin wax continues to be the most popular tissue-embedding medium, due to its low cost and ease of use, facilitating long-term storage of the embedded tissue blocks. To promote good ribbon generation, the paraffin block needs to be sufficiently hard to enable the sections to be cut on the microtome. This is routinely achieved by placing the paraffin blocks on ice, cooling both the tissue and the wax to a similar consistency and swelling the tissue to make it easier to section. As the block heats up, however, the paraffin softens and expands, resulting in corrugation and variations in the consistency of the sections, rendering some unsuitable for use. The Cool Cut Clamp is a peltier-cooled specimen clamp, which helps to address this issue by maintaining the paraffin block at a suitable temperature for sectioning for a prolonged period.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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