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Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

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Science  01 Mar 2013:
Vol. 339, Issue 6123, pp. 1084-1088
DOI: 10.1126/science.1233521

Article Information

vol. 339 no. 6123 1084-1088

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History: 
  • Received for publication December 3, 2012
  • Accepted for publication January 9, 2013
  • .

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Author Information

  1. Janet G. M. Markle1,2,
  2. Daniel N. Frank3,
  3. Steven Mortin-Toth1,
  4. Charles E. Robertson4,
  5. Leah M. Feazel3,
  6. Ulrike Rolle-Kampczyk5,
  7. Martin von Bergen5,6,7,
  8. Kathy D. McCoy8,
  9. Andrew J. Macpherson8,
  10. Jayne S. Danska1,2,9,*
  1. 1Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 1X8, Canada.
  2. 2Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  3. 3Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  4. 4Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
  5. 5Department of Metabolomics, Helmholtz Center for Environmental Research, 04318 Leipzig, Germany.
  6. 6Department of Proteomics, Helmholtz Center for Environmental Research, 04318 Leipzig, Germany.
  7. 7Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, 9000 Aalborg, Denmark.
  8. 8Maurice Müller Laboratories, Universitätsklinik für Viszerale Chirurgie und Medizin (UVCM), University of Bern, 3008 Bern, Switzerland.
  9. 9Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada.
  1. *To whom correspondence should be addressed. E-mail: jayne.danska{at}sickkids.ca

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