Report

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

See allHide authors and affiliations

Science  08 Mar 2013:
Vol. 339, Issue 6124, pp. 1216-1219
DOI: 10.1126/science.1231097

Article Information

vol. 339 no. 6124 1216-1219

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 4, 2012
  • Accepted for publication January 18, 2013
  • .

Author Information

  1. Basil P. Hubbard1,
  2. Ana P. Gomes1,2,
  3. Han Dai3,
  4. Jun Li1,
  5. April W. Case3,
  6. Thomas Considine3,
  7. Thomas V. Riera3,
  8. Jessica E. Lee4,
  9. Sook Yen E4,
  10. Dudley W. Lamming1,*,
  11. Bradley L. Pentelute5,
  12. Eli R. Schuman3,
  13. Linda A. Stevens6,
  14. Alvin J. Y. Ling1,
  15. Sean M. Armour1,
  16. Shaday Michan1,,
  17. Huizhen Zhao7,
  18. Yong Jiang7,
  19. Sharon M. Sweitzer7,
  20. Charles A. Blum3,
  21. Jeremy S. Disch3,
  22. Pui Yee Ng3,
  23. Konrad T. Howitz8,,
  24. Anabela P. Rolo2,9,
  25. Yoshitomo Hamuro4,
  26. Joel Moss6,
  27. Robert B. Perni3,
  28. James L. Ellis3,
  29. George P. Vlasuk3,
  30. David A. Sinclair1,10,§
  1. 1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Center for Neurosciences and Cell Biology, Department of Life Sciences, University of Coimbra, Coimbra 3004-517, Portugal.
  3. 3Sirtris, a GSK Company, Cambridge, MA 02139, USA.
  4. 4ExSAR Corporation, Monmouth Junction, NJ 08852, USA.
  5. 5Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  6. 6NIH Cardiovascular and Pulmonary Branch/National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
  7. 7GlaxoSmithKline, Collegeville, PA 19426, USA.
  8. 8BIOMOL Research Laboratories Inc., Plymouth Meeting, PA 19462, USA.
  9. 9Department of Biology, University of Aveiro, Aveiro 3810-193, Portugal.
  10. 10Department of Pharmacology, University of New South Wales, Sydney, NSW 2052, Australia.
  1. §To whom correspondence should be addressed. E-mail: david_sinclair{at}hms.harvard.edu
  • * Present address: Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

  • Present address: Instituto Nacional de Geriatría, Institutos Nacionales de Salud, México D.F. 04510, México.

  • Present address: Reaction Biology Corporation, Malvern, PA 19355, USA.

Altmetric

Article usage

Article usage: March 2013 to March 2020

AbstractFullPdf
Mar 20134978238805274
Apr 20135762813955
May 20133030464486
Jun 20132080293317
Jul 20131548217211
Aug 20131729196234
Sep 20131579364334
Oct 20131374195207
Nov 20131019137159
Dec 2013102098130
Jan 20141220125171
Feb 2014733124176
Mar 20141059164166
Apr 2014918115326
May 20141037161146
Jun 20145447077
Jul 20144997165
Aug 20144528898
Sep 20144877699
Oct 20146687775
Nov 201465510899
Dec 20144237875
Jan 20154847783
Feb 20153607896
Mar 2015542102108
Apr 20153917970
May 20152924251
Jun 20153237253
Jul 20152855537
Aug 20152384439
Sep 20153194651
Oct 20154237266
Nov 20153405146
Dec 20153424649
Jan 20163203855
Feb 20164102540
Mar 20162624556
Apr 20162823147
May 20163154369
Jun 20163102250
Jul 20162801534
Aug 20163822252
Sep 20163502657
Oct 20163301648
Nov 20165062451
Dec 20163112236
Jan 20172691937
Feb 20172982840
Mar 20173397177
Apr 20172813750
May 20173072847
Jun 20172162442
Jul 20172272136
Aug 2017171720
Sep 20171871436
Oct 20171902035
Nov 20171971328
Dec 20171972330
Jan 20181491418
Feb 20182032922
Mar 20183053248
Apr 20182184556
May 20181811839
Jun 20181951630
Jul 20181912131
Aug 20181403742
Sep 20181506443
Oct 20181274926
Nov 20181463026
Dec 20181243626
Jan 20191492326
Feb 20191694729
Mar 20192606330
Apr 20192014230
May 20192114832
Jun 20191294216
Jul 20192783626
Aug 20192903017
Sep 20193153918
Oct 20193377139
Nov 20192793823
Dec 20192364227
Jan 20202393819
Feb 20202193225
Mar 20202172915

Stay Connected to Science