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The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

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Science  15 Mar 2013:
Vol. 339, Issue 6125, pp. 1335-1338
DOI: 10.1126/science.1232927

Article Information

vol. 339 no. 6125 1335-1338

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History: 
  • Received for publication November 19, 2012
  • Accepted for publication January 25, 2013
  • .

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Author Information

  1. Kohji Mori1,*,
  2. Shih-Ming Weng2,*,
  3. Thomas Arzberger3,
  4. Stephanie May2,
  5. Kristin Rentzsch2,
  6. Elisabeth Kremmer4,
  7. Bettina Schmid2,5,
  8. Hans A. Kretzschmar3,
  9. Marc Cruts6,7,
  10. Christine Van Broeckhoven6,7,
  11. Christian Haass1,2,5,
  12. Dieter Edbauer1,2,5,
  1. 1Adolf Butenandt-Institute, Biochemistry, Ludwig-Maximilians University (LMU) Munich, Schillerstrasse 44, 80336 Munich, Germany.
  2. 2German Center for Neurodegenerative Diseases (DZNE), Munich, Schillerstrasse 44, 80336 Munich, Germany.
  3. 3Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Feodor-Lynen-Strasse 23, 81377 Munich, Germany.
  4. 4Institute of Molecular Immunology, Helmholtz Zentrum München, Marchioninistrasse 25, 81377 Munich, Germany.
  5. 5Munich Cluster of Systems Neurology (SyNergy), Ludwig-Maximilians-University Munich, Schillerstrasse 44, 80336 Munich, Germany.
  6. 6Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Universiteitsplein 1, B-2610 Antwerp, Belgium.
  7. 7Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
  1. To whom correspondence should be addressed. E-mail: dieter.edbauer{at}dzne.de
  1. * These authors contributed equally to this work.

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