Report

Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses

See allHide authors and affiliations

Science  22 Mar 2013:
Vol. 339, Issue 6126, pp. 1448-1453
DOI: 10.1126/science.1233665

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Interfering with Interferons

Infections with Mycobacteria, including Mycobacterium leprae or M. tuberculosis, vary substantially in their clinical presentation. For instance, in some cases of M. leprae, the infection is self-healing with very few lesions. In contrast, some people experience the disseminated form, where skin lesions abound and bacteria are abundant. In patients infected with M. leprae, Teles et al. (p. 1448, published online 28 February) found that the disseminated disease associates with a type I interferon gene signature, whereas the self-healing form associates with a type II interferon gene signature. In cultured cells, type I interferon and its downstream signaling cascade inhibited the antimicrobial response induced by type II interferons, providing a potential explanation for why robust disease rather than protection is seen in some cases of infection.

View Full Text

Stay Connected to Science