Structural Basis for Kinesin-1:Cargo Recognition

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Science  19 Apr 2013:
Vol. 340, Issue 6130, pp. 356-359
DOI: 10.1126/science.1234264

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Cargo-Motor Interaction

Kinesin-1 directs a diverse array of functions within axons by interacting with many proteins. To understand the mechanisms underpinning kinesin-cargo recognition, Pernigo et al. (p. 356, published online 21 March) solved the crystal structure of the tetratricopeptide repeat of kinesin light chain 2 bound to a W-acidic cargo peptide from SKIP—a critical host determinant in Salmonella pathogenesis that controls lysosome positioning.