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An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

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Science  03 May 2013:
Vol. 340, Issue 6132, pp. 626-630
DOI: 10.1126/science.1236062

Article Information

vol. 340 no. 6132 626-630

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History: 
  • Received for publication February 4, 2013
  • Accepted for publication March 18, 2013

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Author Information

  1. Dan Rohle1,2,*,
  2. Janeta Popovici-Muller3,*,
  3. Nicolaos Palaskas1,*,
  4. Sevin Turcan1,*,
  5. Christian Grommes4,
  6. Carl Campos1,
  7. Jennifer Tsoi8,
  8. Owen Clark1,
  9. Barbara Oldrini1,
  10. Evangelia Komisopoulou8,
  11. Kaiko Kunii3,
  12. Alicia Pedraza7,
  13. Stefanie Schalm3,
  14. Lee Silverman3,
  15. Alexandra Miller4,
  16. Fang Wang3,
  17. Hua Yang3,
  18. Yue Chen3,
  19. Andrew Kernytsky3,
  20. Marc K. Rosenblum6,
  21. Wei Liu3,
  22. Scott A. Biller3,
  23. Shinsan M. Su3,
  24. Cameron W. Brennan1,7,
  25. Timothy A. Chan1,5,
  26. Thomas G. Graeber8,,
  27. Katharine E. Yen3,,,
  28. Ingo K. Mellinghoff1,2,4,,
  1. 1Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  2. 2Department of Pharmacology, Weill-Cornell Graduate School of Biomedical Sciences, New York, NY 10021, USA.
  3. 3Agios Pharmaceuticals, Cambridge, MA 02139, USA.
  4. 4Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  5. 5Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  6. 6Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  7. 7Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  8. 8Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California, Los Angeles, CA 90095, USA.
  1. Corresponding author. E-mail: katharine.yen{at}agios.com (K.E.Y.); mellingi{at}mskcc.org (I.K.M.)
  1. * These authors contributed equally to this work.

  2. This work is based on equal contributions from the laboratories of T.G.G., K.E.Y., and I.K.M.

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