10 May 2013
Vol 340, Issue 6133

About The Cover

Cover image expansion

COVER Model of a candidate HIV vaccine prime immunogen (center) engaging germline B cell receptors (bottom) to initiate an antibody immune response. The immunogen is a virus-like nanoparticle, ~30 nanometers in diameter, displaying 60 copies of an HIV gp120 outer domain protein engineered to bind germline precursors of specific broadly neutralizing antibodies. This work has promising implications for HIV vaccine research. See page 711. Image: Christina Corbaci, Adam Gardner, Joe Jardine, Sergey Menis, and William Schief, The Scripps Research Institute