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Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

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Science  28 Jun 2013:
Vol. 340, Issue 6140, pp. 1567-1570
DOI: 10.1126/science.1230381

Article Information

vol. 340 no. 6140 1567-1570

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History: 
  • Received for publication September 18, 2012
  • Accepted for publication April 25, 2013
  • .

Author Information

  1. Esther Lapuente-Brun1,2,*,
  2. Raquel Moreno-Loshuertos2,*,
  3. Rebeca Acín-Pérez1,
  4. Ana Latorre-Pellicer1,
  5. Carmen Colás1,
  6. Eduardo Balsa1,3,
  7. Ester Perales-Clemente1,
  8. Pedro M. Quirós5,
  9. Enrique Calvo1,
  10. M. A. Rodríguez-Hernández4,
  11. Plácido Navas4,
  12. Raquel Cruz6,
  13. Ángel Carracedo6,
  14. Carlos López-Otín5,
  15. Acisclo Pérez-Martos2,
  16. Patricio Fernández-Silva2,
  17. Erika Fernández-Vizarra7,
  18. José Antonio Enríquez1,2,
  1. 1Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
  2. 2Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza 50009, Spain.
  3. 3Servicio de Inmunología, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid 28006, Spain.
  4. 4Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-CSIC and Centro de Investigación Biomédica en Red de Enfermedades Raras, ISCIII, Sevilla 41013 Spain.
  5. 5Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain.
  6. 6Grupo de Medicina Xenómica, Facultad de Medicina, Centro de Investigación Biomédica en Red de Enfermedades Raras, Universidad de Santiago de Compostela 15782 Santiago de Compostela, A Coruña, Spain.
  7. 7IIS Aragón, Unidad de Investigación Traslacional Instituto Aragones de Ciencias de la Salud, Hospital Universitario Miguel Servet, Zaragoza 50009, Spain.
  1. Corresponding author. E-mail: jaenriquez{at}cnic.es
  1. * These authors contributed equally to this work.

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