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Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

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Science  05 Jul 2013:
Vol. 341, Issue 6141, pp. 84-87
DOI: 10.1126/science.1233606

Article Information

vol. 341 no. 6141 84-87

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Print ISSN: 
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History: 
  • Received for publication December 4, 2012
  • Accepted for publication May 9, 2013
  • .

Author Information

  1. Daniel Martinez Molina1,*,
  2. Rozbeh Jafari1,*,
  3. Marina Ignatushchenko1,*,
  4. Takahiro Seki2,
  5. E. Andreas Larsson3,
  6. Chen Dan3,
  7. Lekshmy Sreekumar3,
  8. Yihai Cao2,4,
  9. Pär Nordlund1,3,
  1. 1Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles väg 2, SE-17177 Stockholm, Sweden.
  2. 2Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Nobels väg 16, SE-17177 Stockholm, Sweden.
  3. 3School of Biological Sciences, Nanyang Technological University, 61 Nanyang Drive, Singapore 639798, Singapore.
  4. 4Department of Medicine and Health Sciences, Linköping University, 581 83 Linköping, Sweden.
  1. Corresponding author. E-mail: par.nordlund{at}ki.se
  1. * These authors contributed equally to this work.

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