Sequence-Controlled Polymers

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Science  09 Aug 2013:
Vol. 341, Issue 6146, 1238149
DOI: 10.1126/science.1238149

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Controlled Polymers

Nature has achieved exquisite sequence control in the synthesis of polymers like DNA. In contrast, synthetic polymers rarely have the same fidelity in their chemistry or uniformity in chain-length distribution, especially when more than one monomer is involved. Lutz et al. (1238149) review the progress that has been made in making sequence-controlled polymers of increasing length and complexity. These developments have come from both advances in synthetic chemistry methods and the exploitation of biological machinery.