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Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds

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Science  09 Aug 2013:
Vol. 341, Issue 6146, pp. 651-654
DOI: 10.1126/science.1239278

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Promoting Pluripotency

A specialized mammalian cell can be set back to the pluripotent state either by transfer of the somatic cell nucleus into an oocyte or by delivery of exogenous pluripotency-associated transcription factors. Hou et al. (p. 651, published online 18 July) developed an approach to induce pluripotency in somatic cells using a cocktail of small molecules. The ability to generate such chemically induced pluripotent stem cells may provide an alternate route for therapeutic cloning and for drug development in regenerative medicine.