Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Vanessa K. Ridaura; Jeremiah J. Faith; Federico E. Rey; Jiye Cheng; Alexis E. Duncan; Andrew L. Kau; Nicholas W. Griffin; Vincent Lombard; Bernard Henrissat; James R. Bain; Michael J. Muehlbauer; Olga Ilkayeva; Clay F. Semenkovich; Katsuhiko Funai; David K. Hayashi; Barbara J. Lyle; Margaret C. Martini; Luke K. Ursell; Jose C. Clemente; William Van Treuren; William A. Walters; Rob Knight; Christopher B. Newgard; Andrew C. Heath; Jeffrey I. Gordon

doi:10.1126/science.1241214

Research Article

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Vanessa K. Ridaura¹,
Jeremiah J. Faith¹,
Federico E. Rey¹,
Jiye Cheng¹,
Alexis E. Duncan²,³,
Andrew L. Kau¹,
Nicholas W. Griffin¹,
Vincent Lombard⁴,
Bernard Henrissat⁴,⁵,
James R. Bain⁶,⁷,⁸,
Michael J. Muehlbauer⁶,
Olga Ilkayeva⁶,
Clay F. Semenkovich⁹,
Katsuhiko Funai⁹,
David K. Hayashi¹⁰,
Barbara J. Lyle¹¹,
Margaret C. Martini¹¹,
Luke K. Ursell¹²,
Jose C. Clemente¹²,
William Van Treuren¹²,
William A. Walters¹³,
Rob Knight¹²,¹⁴,¹⁵,
Christopher B. Newgard⁶,⁷,⁸,
Andrew C. Heath²,
Jeffrey I. Gordon¹,*

¹Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
²Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
³George Warren Brown School of Social Work, Washington University, St. Louis, MO 63130, USA.
⁴Architecture et Fonction des Macromolécules Biologiques, CNRS and Aix Marseille Université, CNRS UMR 7257, 13288 Marseille, France.
⁵Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark.
⁶Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.
⁷Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
⁸Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
⁹Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
¹⁰Mondelez International, Glenview, IL 60025, USA.
¹¹Kraft Foods Group, Glenview, IL 60025, USA.
¹²Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
¹³Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
¹⁴Biofrontiers Institute, University of Colorado, Boulder, CO 80309, USA.
¹⁵Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA.

↵*To whom correspondence should be sent. E-mail: jgordon{at}wustl.edu

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Science 06 Sep 2013:
Vol. 341, Issue 6150, 1241214
DOI: 10.1126/science.1241214

Vanessa K. Ridaura

1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

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Jeremiah J. Faith

1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

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Federico E. Rey

1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

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Jiye Cheng

1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

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Alexis E. Duncan

2Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.

3George Warren Brown School of Social Work, Washington University, St. Louis, MO 63130, USA.

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Andrew L. Kau

1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

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Nicholas W. Griffin

1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

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Vincent Lombard

4Architecture et Fonction des Macromolécules Biologiques, CNRS and Aix Marseille Université, CNRS UMR 7257, 13288 Marseille, France.

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Bernard Henrissat

4Architecture et Fonction des Macromolécules Biologiques, CNRS and Aix Marseille Université, CNRS UMR 7257, 13288 Marseille, France.

5Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark.

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James R. Bain

6Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.

7Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

8Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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Michael J. Muehlbauer

6Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.

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Olga Ilkayeva

6Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.

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Clay F. Semenkovich

9Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Katsuhiko Funai

9Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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David K. Hayashi

10Mondelez International, Glenview, IL 60025, USA.

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Barbara J. Lyle

11Kraft Foods Group, Glenview, IL 60025, USA.

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Margaret C. Martini

11Kraft Foods Group, Glenview, IL 60025, USA.

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Luke K. Ursell

12Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.

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Jose C. Clemente

12Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.

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William Van Treuren

12Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.

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William A. Walters

13Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

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Rob Knight

12Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.

14Biofrontiers Institute, University of Colorado, Boulder, CO 80309, USA.

15Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA.

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Christopher B. Newgard

6Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.

7Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

8Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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Andrew C. Heath

2Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.

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Jeffrey I. Gordon

1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

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For correspondence: jgordon@wustl.edu

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Mice carrying gut bacteria from lean humans protect their cage mates from the effects of gut bacteria from fat humans. [Also see Perspective by Walker and Parkhill]

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

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