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Research Article
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
- Vanessa K. Ridaura1,
- Jeremiah J. Faith1,
- Federico E. Rey1,
- Jiye Cheng1,
- Alexis E. Duncan2,3,
- Andrew L. Kau1,
- Nicholas W. Griffin1,
- Vincent Lombard4,
- Bernard Henrissat4,5,
- James R. Bain6,7,8,
- Michael J. Muehlbauer6,
- Olga Ilkayeva6,
- Clay F. Semenkovich9,
- Katsuhiko Funai9,
- David K. Hayashi10,
- Barbara J. Lyle11,
- Margaret C. Martini11,
- Luke K. Ursell12,
- Jose C. Clemente12,
- William Van Treuren12,
- William A. Walters13,
- Rob Knight12,14,15,
- Christopher B. Newgard6,7,8,
- Andrew C. Heath2,
- Jeffrey I. Gordon1,*
- 1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
- 2Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 3George Warren Brown School of Social Work, Washington University, St. Louis, MO 63130, USA.
- 4Architecture et Fonction des Macromolécules Biologiques, CNRS and Aix Marseille Université, CNRS UMR 7257, 13288 Marseille, France.
- 5Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark.
- 6Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.
- 7Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
- 8Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
- 9Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 10Mondelez International, Glenview, IL 60025, USA.
- 11Kraft Foods Group, Glenview, IL 60025, USA.
- 12Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
- 13Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
- 14Biofrontiers Institute, University of Colorado, Boulder, CO 80309, USA.
- 15Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA.
- ↵*To whom correspondence should be sent. E-mail: jgordon{at}wustl.edu
See allHide authors and affiliations
Science 06 Sep 2013:
Vol. 341, Issue 6150, 1241214
DOI: 10.1126/science.1241214
Vol. 341, Issue 6150, 1241214
DOI: 10.1126/science.1241214
Vanessa K. Ridaura
1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Jeremiah J. Faith
1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Federico E. Rey
1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Jiye Cheng
1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Alexis E. Duncan
2Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
3George Warren Brown School of Social Work, Washington University, St. Louis, MO 63130, USA.
Andrew L. Kau
1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Nicholas W. Griffin
1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Vincent Lombard
4Architecture et Fonction des Macromolécules Biologiques, CNRS and Aix Marseille Université, CNRS UMR 7257, 13288 Marseille, France.
Bernard Henrissat
4Architecture et Fonction des Macromolécules Biologiques, CNRS and Aix Marseille Université, CNRS UMR 7257, 13288 Marseille, France.
5Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark.
James R. Bain
6Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.
7Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
8Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
Michael J. Muehlbauer
6Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.
Olga Ilkayeva
6Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.
Clay F. Semenkovich
9Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Katsuhiko Funai
9Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
David K. Hayashi
10Mondelez International, Glenview, IL 60025, USA.
Barbara J. Lyle
11Kraft Foods Group, Glenview, IL 60025, USA.
Margaret C. Martini
11Kraft Foods Group, Glenview, IL 60025, USA.
Luke K. Ursell
12Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
Jose C. Clemente
12Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
William Van Treuren
12Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
William A. Walters
13Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
Rob Knight
12Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
14Biofrontiers Institute, University of Colorado, Boulder, CO 80309, USA.
15Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA.
Christopher B. Newgard
6Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.
7Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
8Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
Andrew C. Heath
2Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jeffrey I. Gordon
1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
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