You are currently viewing the summary.
View Full TextLog in to view the full text
AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.
More options
Download and print this article for your personal scholarly, research, and educational use.
Buy a single issue of Science for just $15 USD.
Summary
Mitochondrial diseases [often caused by mutations in mitochondrial DNA (mtDNA)] can manifest in a range of severe symptoms, for which there are currently no cures (1). The diseases are passed from mothers to offspring. Intense research efforts have recently focused on a germline therapeutic strategy to prevent the inheritance of disease-causing mitochondria. However, although there has been increased government interest, especially in the United Kingdom, for using this approach to treat patients, there are reasons to believe that it is premature to move this technology into the clinic at this stage.
