A Looser Clock to Cure Jet Lag

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Science  04 Oct 2013:
Vol. 342, Issue 6154, pp. 52-53
DOI: 10.1126/science.1245474

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Jet lag is a blessing to circadian biologists because the disruption of mental and physical well-being immediately highlights the importance of our internal “body clock.” It is also a curse because jet lag has so far eluded attempts at a cure. On page 85 of this issue, Yamaguchi et al. (1) show that mice lacking receptors for the neuropeptide arginine vasopressin (AVP) are resistant to jet lag, providing new hope of overcoming this modern malaise. Not only may this help us recover from symptoms of jet lag, but it should also help unravel the neural circuit that sets the tempo to our lives.