You are currently viewing the summary.
View Full TextLog in to view the full text
AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.
More options
Download and print this article for your personal scholarly, research, and educational use.
Buy a single issue of Science for just $15 USD.
Summary
RNA interference (RNAi) is an evolutionarily conserved pathway in cells for potent and specific silencing of gene expression. It is triggered by the accumulation of double-stranded RNA (dsRNA), which is subsequently processed into small interfering RNA (siRNA) and taken up into a protein complex that silences genes by cleaving their complementary RNAs (1). This mechanism has an important function in immunity against viruses in infected plants and invertebrates, but whether this is true in mammals has been widely debated (2). On pages 235 and 231 of this issue, Maillard et al. (3) and Li et al. (4) provide evidence for the existence of a functional antiviral RNAi pathway in mammalian cells.