Report

Sleep Drives Metabolite Clearance from the Adult Brain

See allHide authors and affiliations

Science  18 Oct 2013:
Vol. 342, Issue 6156, pp. 373-377
DOI: 10.1126/science.1241224

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Taking Out the Trash

The purpose of sleep remains mysterious. Using state-of-the-art in vivo two-photon imaging to directly compare two arousal states in the same mouse, Xie et al. (p. 373; see the Perspective by Herculano-Houzel) found that metabolic waste products of neural activity were cleared out of the sleeping brain at a faster rate than during the awake state. This finding suggests a mechanistic explanation for how sleep serves a restorative function, in addition to its well-described effects on memory consolidation.

View Full Text