Sleep Drives Metabolite Clearance from the Adult Brain

Lulu Xie; Hongyi Kang; Qiwu Xu; Michael J. Chen; Yonghong Liao; Meenakshisundaram Thiyagarajan; John O’Donnell; Daniel J. Christensen; Charles Nicholson; Jeffrey J. Iliff; Takahiro Takano; Rashid Deane; Maiken Nedergaard

doi:10.1126/science.1241224

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Sleep Drives Metabolite Clearance from the Adult Brain

Lulu Xie¹,*,
Hongyi Kang¹,*,
Qiwu Xu¹,
Michael J. Chen¹,
Yonghong Liao¹,
Meenakshisundaram Thiyagarajan¹,
John O’Donnell¹,
Daniel J. Christensen¹,
Charles Nicholson²,
Jeffrey J. Iliff¹,
Takahiro Takano¹,
Rashid Deane¹,
Maiken Nedergaard¹,†

¹Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
²Department of Neuroscience and Physiology, Langone Medical Center, New York University, New York, NY 10016, USA.

↵†Corresponding author. E-mail: nedergaard{at}urmc.rochester.edu

↵* These authors contributed equally to this work.

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Science 18 Oct 2013:
Vol. 342, Issue 6156, pp. 373-377
DOI: 10.1126/science.1241224

Lulu Xie

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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Hongyi Kang

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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Qiwu Xu

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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Michael J. Chen

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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Yonghong Liao

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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Meenakshisundaram Thiyagarajan

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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John O’Donnell

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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Daniel J. Christensen

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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Charles Nicholson

Department of Neuroscience and Physiology, Langone Medical Center, New York University, New York, NY 10016, USA.

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Jeffrey J. Iliff

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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Takahiro Takano

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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Rashid Deane

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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Maiken Nedergaard

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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For correspondence: nedergaard@urmc.rochester.edu

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Sleep Drives Metabolite Clearance from the Adult Brain

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