Identification of Genetic Variants That Affect Histone Modifications in Human Cells

Graham McVicker; Bryce van de Geijn; Jacob F. Degner; Carolyn E. Cain; Nicholas E. Banovich; Anil Raj; Noah Lewellen; Marsha Myrthil; Yoav Gilad; Jonathan K. Pritchard

doi:10.1126/science.1242429

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Identification of Genetic Variants That Affect Histone Modifications in Human Cells

Graham McVicker¹,²,*,
Bryce van de Geijn¹,³,*,
Jacob F. Degner¹,³,
Carolyn E. Cain¹,
Nicholas E. Banovich¹,
Anil Raj¹,⁴,
Noah Lewellen²,
Marsha Myrthil²,
Yoav Gilad¹,†,
Jonathan K. Pritchard¹,²,⁴,⁵,†

¹Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
²Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
³Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA.
⁴Department of Genetics, Stanford University, Stanford, CA 94305, USA.
⁵Department of Biology, Stanford University, Stanford, CA 94305, USA.

↵†Corresponding author. E-mail: gilad{at}uchicago.edu (Y.G.); pritch{at}stanford.edu (J.K.P.)

↵* These authors contributed equally to this study.

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Science 08 Nov 2013:
Vol. 342, Issue 6159, pp. 747-749
DOI: 10.1126/science.1242429

Graham McVicker

1Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

2Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

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For correspondence: gilad@uchicago.edu pritch@stanford.edu

Bryce van de Geijn

1Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

3Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA.

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For correspondence: gilad@uchicago.edu pritch@stanford.edu

Jacob F. Degner

1Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

3Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA.

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Carolyn E. Cain

1Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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Nicholas E. Banovich

1Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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Anil Raj

1Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

4Department of Genetics, Stanford University, Stanford, CA 94305, USA.

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Noah Lewellen

2Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

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Marsha Myrthil

2Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

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Yoav Gilad

1Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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Jonathan K. Pritchard

1Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

2Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

4Department of Genetics, Stanford University, Stanford, CA 94305, USA.

5Department of Biology, Stanford University, Stanford, CA 94305, USA.

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Identification of Genetic Variants That Affect Histone Modifications in Human Cells

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