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Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

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Science  15 Nov 2013:
Vol. 342, Issue 6160, pp. 866-871
DOI: 10.1126/science.1243292

Article Information

vol. 342 no. 6160 866-871

PubMed: 
Print ISSN: 
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History: 
  • Received for publication July 16, 2013
  • Accepted for publication September 23, 2013
  • .

Author Information

  1. Ivan Angulo1,*,
  2. Oscar Vadas2,*,,
  3. Fabien Garçon3,*,
  4. Edward Banham-Hall3,*,
  5. Vincent Plagnol4,
  6. Timothy R. Leahy5,6,
  7. Helen Baxendale7,
  8. Tanya Coulter6,8,
  9. James Curtis1,
  10. Changxin Wu1,
  11. Katherine Blake-Palmer1,
  12. Olga Perisic2,
  13. Deborah Smyth9,
  14. Mailis Maes1,
  15. Christine Fiddler1,
  16. Jatinder Juss1,
  17. Deirdre Cilliers10,
  18. Gašper Markelj11,
  19. Anita Chandra7,
  20. George Farmer12,
  21. Anna Kielkowska13,
  22. Jonathan Clark13,
  23. Sven Kracker14,15,
  24. Marianne Debré16,
  25. Capucine Picard15,16,17,
  26. Isabelle Pellier18,
  27. Nada Jabado19,
  28. James A. Morris20,
  29. Gabriela Barcenas-Morales21,
  30. Alain Fischer14,15,16,
  31. Len Stephens3,
  32. Phillip Hawkins3,
  33. Jeffrey C. Barrett20,
  34. Mario Abinun5,
  35. Menna Clatworthy1,
  36. Anne Durandy14,15,16,17,
  37. Rainer Doffinger7,
  38. Edwin R. Chilvers1,
  39. Andrew J. Cant5,
  40. Dinakantha Kumararatne7,
  41. Klaus Okkenhaug3,
  42. Roger L. Williams2,
  43. Alison Condliffe1,,
  44. Sergey Nejentsev1,§
  1. 1Department of Medicine, University of Cambridge, Cambridge, UK.
  2. 2Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.
  3. 3The Babraham Institute, Cambridge, UK.
  4. 4University College London Genetics Institute, University College London, London, UK.
  5. 5Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
  6. 6Our Lady’s Children’s Hospital, Crumlin, Dublin, Ireland.
  7. 7Department of Clinical Biochemistry and Immunology, Addenbrooke’s Hospital, Cambridge, UK.
  8. 8Department of Immunology, School of Medicine, Trinity College, Dublin, Ireland.
  9. 9Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
  10. 10Department of Clinical Genetics, Oxford University Hospitals, Oxford, UK.
  11. 11Department of Allergology, Rheumatology and Clinical Immunology, University Children’s Hospital, University Medical Center, Ljubljana, Slovenia.
  12. 12Raigmore Hospital, Inverness, UK.
  13. 13Babraham Bioscience Technologies Ltd, Babraham Research Campus, Cambridge, UK.
  14. 14National Institute of Health and Medical Research INSERM U768, Necker Children’s Hospital, Paris, France.
  15. 15Descartes-Sorbonne Paris Cité University of Paris, Imagine Institute, Paris, France.
  16. 16Department of Immunology and Hematology, Assistance Publique-Hopitaux de Paris, Necker Children’s Hospital, Paris, France.
  17. 17Center for Primary Immunodeficiencies (CEDI), Assistance Publique-Hopitaux de Paris, Necker Children’s Hospital, Paris, France.
  18. 18Department of Pediatrics, Centre Hospital Universitaire, Angers, France.
  19. 19Department of Pediatrics, McGill University and McGill University Health Center, Montreal, Canada.
  20. 20Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  21. 21Laboratorio de Inmunologia, Unam, Fes-Cuautitlan, Mexico.
  1. §Corresponding author. E-mail: sn262{at}cam.ac.uk
  1. * These authors contributed equally to this work.

  2. These authors contributed equally to this work.

  • Present address: Department of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.

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