PerspectiveMolecular Biology

Chromosome Capture Brings It All Together

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Science  22 Nov 2013:
Vol. 342, Issue 6161, pp. 940-941
DOI: 10.1126/science.1247514

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The organization and morphogenesis of chromosomes as they prepare to segregate during cell division have fascinated researchers since their first microscopic visualizations. On page 948 of this issue, Naumova et al. (1) combine chromosome conformation capture with polymer physics simulations to see inside metaphase chromosomes and elucidate their principles of organization. A new, yet satisfyingly familiar, view emerges.