Report

Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

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Science  22 Nov 2013:
Vol. 342, Issue 6161, pp. 976-979
DOI: 10.1126/science.1244730

Article Information

vol. 342 no. 6161 976-979

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 15, 2013
  • Accepted for publication October 17, 2013
  • .

Author Information

  1. Björn F. Koel1,
  2. David F. Burke2,3,
  3. Theo M. Bestebroer1,
  4. Stefan van der Vliet1,
  5. Gerben C. M. Zondag4,5,
  6. Gaby Vervaet1,
  7. Eugene Skepner2,3,
  8. Nicola S. Lewis2,3,
  9. Monique I. J. Spronken1,
  10. Colin A. Russell3,6,
  11. Mikhail Y. Eropkin7,
  12. Aeron C. Hurt8,
  13. Ian G. Barr8,
  14. Jan C. de Jong1,
  15. Guus F. Rimmelzwaan1,
  16. Albert D. M. E. Osterhaus1,
  17. Ron A. M. Fouchier1,*,
  18. Derek J. Smith1,2,3,9,*
  1. 1Department of Viroscience, Erasmus MC, 3015GE Rotterdam, Netherlands.
  2. 2Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.
  3. 3WHO Collaborating Centre for Modeling Evolution and Control of Emerging Infectious Diseases, University of Cambridge, Cambridge CB2 3EJ, UK.
  4. 4BaseClear B.V., 2333CC Leiden, Netherlands.
  5. 5Luris, Leiden University, 2333AA Leiden, Netherlands.
  6. 6Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.
  7. 7Research Institute of Influenza, 197376 St. Petersburg, Russia.
  8. 8WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Melbourne, Victoria 3051, Australia.
  9. 9Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.
  1. *Corresponding author. E-mail: dsmith{at}zoo.cam.ac.uk (D.J.S.); r.fouchier{at}erasmusmc.nl (R.A.M.F.)

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