Cell Biology

Centriole Central

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Science  20 Dec 2013:
Vol. 342, Issue 6165, pp. 1418
DOI: 10.1126/science.342.6165.1418-b

The centriole is an evolutionarily conserved organelle involved in microtubule organization. Pairs of centrioles form the centrosome, which is the major microtubule-organizing center in interphase and the mitotic cells of higher animals. Centriole number is subjected to tight regulation, and aberrant centriole numbers cause genome instability and cell proliferation defects, leading to tumorigenesis and other diseases. The centriole also forms the basal body of the cilium, a microtubule-based tail-like membrane protrusion. Epithelial cells, such as those seen lining the trachea, contain many cilia on their apical surface. How are the hundreds of centrioles required for multiciliogenesis created? Zhao et al. examined multicilia formation in mouse tissues and cell lines using super-resolution three-dimensional structured illumination microscopy. Multiple centrioles were produced in ring-shaped deuterosome structures. Two related genes, Cep63 and Deup1, were important for the generation of centrioles, with Deup67 being essential for assembling the deuterosome structures required to create multiple centrioles de novo. Cep63, on the other hand, was more important for mother-centriole–based centriole duplication.

Nat. Cell Biol. 15, 1434 (2013).

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