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mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

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Science  20 Dec 2013:
Vol. 342, Issue 6165, pp. 1524-1528
DOI: 10.1126/science.1244360

Article Information

vol. 342 no. 6165 1524-1528

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Print ISSN: 
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History: 
  • Received for publication August 7, 2013
  • Accepted for publication November 6, 2013

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Author Information

  1. Simon C. Johnson1,
  2. Melana E. Yanos1,2,
  3. Ernst-Bernhard Kayser3,
  4. Albert Quintana4,
  5. Maya Sangesland1,
  6. Anthony Castanza1,
  7. Lauren Uhde1,
  8. Jessica Hui1,
  9. Valerie Z. Wall1,
  10. Arni Gagnidze1,
  11. Kelly Oh1,
  12. Brian M. Wasko1,
  13. Fresnida J. Ramos1,
  14. Richard D. Palmiter4,
  15. Peter S. Rabinovitch1,
  16. Philip G. Morgan3,
  17. Margaret M. Sedensky3,
  18. Matt Kaeberlein1,*
  1. 1Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  2. 2Department of Psychology, University of Washington, Seattle, WA 98195, USA.
  3. 3Anesthesiology and Pain Medicine, Seattle Children’s Hospital, Seattle, WA 98105, USA.
  4. 4Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  1. *Corresponding author. E-mail: kaeber{at}uw.edu

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