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Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

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Science  03 Jan 2014:
Vol. 343, Issue 6166, pp. 88-91
DOI: 10.1126/science.1243211

Article Information

vol. 343 no. 6166 88-91

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History: 
  • Received for publication July 15, 2013
  • Accepted for publication October 29, 2013
  • .

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Author Information

  1. Lorenzo Costantino1,*,
  2. Sotirios K. Sotiriou1,*,
  3. Juha K. Rantala2,*,,
  4. Simon Magin3,
  5. Emil Mladenov3,
  6. Thomas Helleday4,
  7. James E. Haber5,
  8. George Iliakis3,
  9. Olli P. Kallioniemi6,
  10. Thanos D. Halazonetis1,
  1. 1Department of Molecular Biology, University of Geneva, 1205 Geneva, Switzerland.
  2. 2Medical Biotechnology, VTT Technical Research Centre of Finland, 20521 Turku, Finland.
  3. 3Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, 45122 Essen, Germany.
  4. 4Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17121 Stockholm, Sweden.
  5. 5Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454, USA.
  6. 6Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00140 Helsinki, Finland.
  1. Corresponding author. E-mail: thanos.halazonetis{at}unige.ch
  1. * These authors contributed equally to this work.

  • Present address: Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA.

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