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The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

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Science  17 Jan 2014:
Vol. 343, Issue 6168, pp. 305-309
DOI: 10.1126/science.1244917

Article Information

vol. 343 no. 6168 305-309

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 20, 2013
  • Accepted for publication November 12, 2013
  • .

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Author Information

  1. Gang Lu1,
  2. Richard E. Middleton1,2,
  3. Huahang Sun1,2,
  4. MarkVic Naniong1,2,
  5. Christopher J. Ott1,
  6. Constantine S. Mitsiades1,
  7. Kwok-Kin Wong1,2,
  8. James E. Bradner1,
  9. William G. Kaelin Jr.1,3,*
  1. 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  2. 2Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  3. 3Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  1. *Corresponding author. E-mail: william_kaelin{at}dfci.harvard.edu

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Article usage: November 2013 to November 2019

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