Review

Development-Inspired Reprogramming of the Mammalian Central Nervous System

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Science  31 Jan 2014:
Vol. 343, Issue 6170, 1239882
DOI: 10.1126/science.1239882

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Repairing the Brain

Research with stem cells and reprogramming of cellular fates is leading to improved understanding of neurodevelopmental events, as well as opening doors to possible cellular replacement therapies. Amamoto and Arlotta (10.1126/science.1239882) review recent progress in this field and highlight the discoveries made and the remaining challenges as stem-cell technologies are applied to cells of the central nervous system.