Editing of Targeted Genes Proved Possible in Monkeys

See allHide authors and affiliations

Science  31 Jan 2014:
Vol. 343, Issue 6170, pp. 476-477
DOI: 10.1126/science.343.6170.476

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Using a recently developed genome-editing technique called CRISPR, a Chinese team has successfully altered two target genes in cynomolgus monkeys, paving the way for the development of monkey models that mimic human diseases. This is the first evidence that CRISPR can work in primates and represents a big advance over previous successes in genetically modifying monkeys, in which genes were inserted randomly into the genome. Only two of the three target genes were modified, and not all cells carry the same modification, indicating more work needs to be done to perfect the timing of the modification. Beyond its significance for biomedical research, the new work raises the possibility that CRISPR will one day be used to change the genetic makeup of human embryos.

  • With reporting by Mara Hvistendahl.

View Full Text

Stay Connected to Science