Research Article

Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders

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Science  31 Jan 2014:
Vol. 343, Issue 6170, pp. 506-511
DOI: 10.1126/science.1247363

Article Information

vol. 343 no. 6170 506-511

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History: 
  • Received for publication October 18, 2013
  • Accepted for publication December 11, 2013
  • .

Author Information

  1. Gaia Novarino1,*,,
  2. Ali G. Fenstermaker1,*,
  3. Maha S. Zaki3,*,
  4. Matan Hofree2,
  5. Jennifer L. Silhavy1,
  6. Andrew D. Heiberg1,
  7. Mostafa Abdellateef1,
  8. Basak Rosti1,
  9. Eric Scott1,
  10. Lobna Mansour4,
  11. Amira Masri5,
  12. Hulya Kayserili6,
  13. Jumana Y. Al-Aama7,
  14. Ghada M. H. Abdel-Salam3,
  15. Ariana Karminejad8,
  16. Majdi Kara9,
  17. Bulent Kara10,
  18. Bita Bozorgmehri8,
  19. Tawfeg Ben-Omran11,
  20. Faezeh Mojahedi12,
  21. Iman Gamal El Din Mahmoud4,
  22. Naima Bouslam13,
  23. Ahmed Bouhouche13,
  24. Ali Benomar13,
  25. Sylvain Hanein14,
  26. Laure Raymond14,
  27. Sylvie Forlani14,
  28. Massimo Mascaro1,
  29. Laila Selim4,
  30. Nabil Shehata15,
  31. Nasir Al-Allawi16,
  32. P.S. Bindu17,
  33. Matloob Azam18,
  34. Murat Gunel19,
  35. Ahmet Caglayan19,
  36. Kaya Bilguvar19,
  37. Aslihan Tolun20,
  38. Mahmoud Y. Issa3,
  39. Jana Schroth1,
  40. Emily G. Spencer1,
  41. Rasim O. Rosti1,
  42. Naiara Akizu1,
  43. Keith K. Vaux1,
  44. Anide Johansen1,
  45. Alice A. Koh1,
  46. Hisham Megahed3,
  47. Alexandra Durr14,21,
  48. Alexis Brice14,21,22,
  49. Giovanni Stevanin14,21,22,23,
  50. Stacy B. Gabriel24,
  51. Trey Ideker2,
  52. Joseph G. Gleeson1,
  1. 1Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093, USA.
  2. 2Department of Computer Science and Engineering and Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  3. 3Clinical Genetics Department, Human Genetics and Genome Research Division, National Research Center, Cairo 12311, Egypt.
  4. 4Department of Pediatric Neurology, Neurometabolic Unit, Cairo University Children’s Hospital, Cairo 406, Egypt.
  5. 5Division of Child Neurology, Department of Pediatrics, University of Jordan, Amman 11942, Jordan.
  6. 6Istanbul University, Istanbul Medical Faculty, Medical Genetics Department, 34093 Istanbul, Turkey.
  7. 7Department of Genetic Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
  8. 8Kariminejad-Najmabadi Pathology and Genetics Center, Tehran, Iran.
  9. 9Department of Pediatrics, Tripoli Children’s Hospital, Tripoli, Libya.
  10. 10Kocaeli University, Medical Faculty, Department of Pediatric Neurology, 41380 Umuttepe, Kocaeli, Turkey.
  11. 11Clinical and Metabolic Genetics Division, Department of Pediatrics, Hamad Medical Corporation, Doha 3050, Qatar.
  12. 12Mashhad Medical Genetic Counseling Center, 91767 Mashhad, Iran.
  13. 13Université Mohammed V Souissi, Equipe de Recherché de Maladies Neurodégéneratives (ERMN) and Centre de Recherche en Épidémiologie Clinique et Essais Thérapeutiques (CRECET), 6402 Rabat, Morocco.
  14. 14Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, INSERM U1127, CNRS UMR7225; UPMC Univ Paris VI UMR_S975, 75013 Paris, France.
  15. 15Department of Pediatrics and Neonatology, Saudi German Hospital, Post Office Box 84348, Riyadh, Kingdom of Saudi Arabia.
  16. 16Department of Pathology, School of Medicine, University of Dohuk, Dohuk, Iraq.
  17. 17Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.
  18. 18Department of Pediatrics and Child Neurology, Wah Medical College, Wah Cantt, Pakistan.
  19. 19Department of Genetics and Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA.
  20. 20Department of Molecular Biology and Genetics, Bogazici University, 34342 Istanbul, Turkey.
  21. 21Assistance Publique–Hôpitaux de Paris, Fédération de Génétique, Pitié-Salpêtrière Hospital, 75013 Paris, France.
  22. 22Institut du Cerveau et de la Moelle Épinière, 75013 Paris, France.
  23. 23Laboratoire de Neurogénétique, Ecole Pratique des Hautes Etudes, Institut du Cerveau et de la Moelle Épinière, 75013 Paris, France.
  24. 24Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  1. Corresponding author. E-mail: jogleeson{at}ucsd.edu
  1. * These authors contributed equally to this work.

  • Present address: IST Austria (Institute of Science and Technology Austria), Klosterneuburg, Austria.

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