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Origin and Spread of de Novo Genes in Drosophila melanogaster Populations

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Science  14 Feb 2014:
Vol. 343, Issue 6172, pp. 769-772
DOI: 10.1126/science.1248286

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Losses and Gains

In order to better understand the process by which de novo genes originate, Zhao et al. (p. 769, published online 23 January) examined testis-based gene expression among Drosophila melanogaster strains and identified both fixed and polymorphic de novo genes. The results suggest that spontaneous activation of previously noncoding DNA may be an important factor in generating genetic novelty.

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