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FDA Considers Trials of 'Three-Parent Embryos'

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Science  21 Feb 2014:
Vol. 343, Issue 6173, pp. 827-828
DOI: 10.1126/science.343.6173.827

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An experimental technique, called mitochondrial DNA replacement therapy, that manipulates a woman's DNA could spare her from passing on a potentially deadly disease to her children. But the technique breaks new and ethically fraught ground: It would create a child that has DNA from "three parents"—the mother, the father, and an egg donor. Now, regulators on both sides of the Atlantic are grappling with whether to allow the first human trials of the technique to go forward.