Research Article

Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

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Science  07 Mar 2014:
Vol. 343, Issue 6175, 1246980
DOI: 10.1126/science.1246980

Article Information

vol. 343 no. 6175

PubMed: 
Print ISSN: 
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History: 
  • Received for publication October 8, 2013
  • Accepted for publication January 10, 2014

Author Information

  1. Mark N. Lee1,2,3,*,
  2. Chun Ye1,*,
  3. Alexandra-Chloé Villani1,2,
  4. Towfique Raj1,2,4,
  5. Weibo Li1,3,
  6. Thomas M. Eisenhaure1,3,
  7. Selina H. Imboywa2,
  8. Portia I. Chipendo2,
  9. F. Ann Ran1,5,6,7,8,
  10. Kamil Slowikowski9,
  11. Lucas D. Ward1,10,
  12. Khadir Raddassi11,
  13. Cristin McCabe1,4,
  14. Michelle H. Lee2,
  15. Irene Y. Frohlich2,
  16. David A. Hafler8,
  17. Manolis Kellis1,10,
  18. Soumya Raychaudhuri1,2,12,13,
  19. Feng Zhang6,7,8,
  20. Barbara E. Stranger14,15,
  21. Christophe O. Benoist2,
  22. Philip L. De Jager1,2,4,
  23. Aviv Regev1,16,17,,
  24. Nir Hacohen1,2,3,
  1. 1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  2. 2Harvard Medical School, Boston, MA 02115, USA.
  3. 3Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA.
  4. 4Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  5. 5Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
  6. 6McGovern Institute for Brain Research, MIT, Cambridge, MA 02139, USA.
  7. 7Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.
  8. 8Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
  9. 9Bioinformatics and Integrative Genomics, Graduate School of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA.
  10. 10Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA.
  11. 11Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA.
  12. 12Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  13. 13Arthritis Research UK Epidemiology Unit, Musculoskeletal Research Group, University of Manchester, Manchester Academic Health Sciences Centre, Manchester M13 9NT, UK.
  14. 14Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637, USA.
  15. 15Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL 60637, USA.
  16. 16Department of Biology, MIT, Cambridge, MA 02139, USA.
  17. 17Howard Hughes Medical Institute.
  1. Corresponding author. E-mail: aregev{at}broad.mit.edu (A.R.); nhacohen{at}partners.org (N.H.)

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