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Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

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Science  02 May 2014:
Vol. 344, Issue 6183, pp. 519-523
DOI: 10.1126/science.1249547

Article Information

vol. 344 no. 6183 519-523

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History: 
  • Received for publication December 11, 2013
  • Accepted for publication April 8, 2014

Author Information

  1. Towfique Raj1,2,3,4,
  2. Katie Rothamel5,
  3. Sara Mostafavi6,
  4. Chun Ye4,
  5. Mark N. Lee3,4,
  6. Joseph M. Replogle1,4,
  7. Ting Feng5,
  8. Michelle Lee1,
  9. Natasha Asinovski5,
  10. Irene Frohlich1,
  11. Selina Imboywa1,
  12. Alina Von Korff1,
  13. Yukinori Okada2,3,4,7,8,
  14. Nikolaos A. Patsopoulos1,2,3,4,
  15. Scott Davis5,
  16. Cristin McCabe1,4,
  17. Hyun-il Paik5,
  18. Gyan P. Srivastava1,2,3,4,
  19. Soumya Raychaudhuri2,3,4,9,
  20. David A. Hafler4,10,
  21. Daphne Koller6,
  22. Aviv Regev4,11,
  23. Nir Hacohen4,12,
  24. Diane Mathis5,
  25. Christophe Benoist5,*,
  26. Barbara E. Stranger13,14,*,
  27. Philip L. De Jager1,2,3,4,*
  1. 1Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  2. 2Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  3. 3Harvard Medical School, Boston, MA 02115, USA.
  4. 4The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  5. 5Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA 02115, USA.
  6. 6Department of Computer Science, Stanford University, Stanford, CA 94305, USA.
  7. 7Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  8. 8Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  9. 9Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  10. 10Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
  11. 11Department of Biology, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, Cambridge, MA 02139, USA.
  12. 12Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA.
  13. 13Section of Genetic Medicine, Department of Medicine, University of Chicago, IL 60637, USA.
  14. 14Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA.
  1. *Corresponding author. E-mail: christophe_benoist{at}hms.harvard.edu (C.B.); bstranger{at}medicine.bsd.uchicago.edu (B.E.S.); pdejager{at}partners.org (P.L.D.J.)

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