Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

Katherine G. Akers; Alonso Martinez-Canabal; Leonardo Restivo; Adelaide P. Yiu; Antonietta De Cristofaro; Hwa-Lin (Liz) Hsiang; Anne L. Wheeler; Axel Guskjolen; Yosuke Niibori; Hirotaka Shoji; Koji Ohira; Blake A. Richards; Tsuyoshi Miyakawa; Sheena A. Josselyn; Paul W. Frankland

doi:10.1126/science.1248903

Research Article

Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

Katherine G. Akers¹,*,
Alonso Martinez-Canabal¹,²,*,
Leonardo Restivo¹,*,
Adelaide P. Yiu¹,
Antonietta De Cristofaro¹,
Hwa-Lin (Liz) Hsiang¹,²,
Anne L. Wheeler¹,²,
Axel Guskjolen¹,³,
Yosuke Niibori¹,
Hirotaka Shoji⁴,
Koji Ohira⁴,
Blake A. Richards¹,
Tsuyoshi Miyakawa⁴,
Sheena A. Josselyn¹,²,³,⁵,^†,
Paul W. Frankland¹,²,³,⁵,^†

¹Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.
²Institute of Medical Science, University of Toronto, Toronto, M5S 1A8, Canada.
³Department of Physiology, University of Toronto, Toronto, M5S 1A8, Canada.
⁴Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, 470-1192, Japan.
⁵Department of Psychology, University of Toronto, Toronto, M5S 3GM, Canada.

↵†Corresponding author. E-mail: paul.frankland{at}sickkids.ca (P.W.F.), sheena.josselyn{at}sickkids.ca (S.A.J.)

↵* These authors contributed equally to this work.

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Science 09 May 2014:
Vol. 344, Issue 6184, pp. 598-602
DOI: 10.1126/science.1248903

Katherine G. Akers

1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

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Alonso Martinez-Canabal

1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

2Institute of Medical Science, University of Toronto, Toronto, M5S 1A8, Canada.

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Leonardo Restivo

1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

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Adelaide P. Yiu

1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

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Antonietta De Cristofaro

1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

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Hwa-Lin (Liz) Hsiang

1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

2Institute of Medical Science, University of Toronto, Toronto, M5S 1A8, Canada.

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Anne L. Wheeler

1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

2Institute of Medical Science, University of Toronto, Toronto, M5S 1A8, Canada.

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Axel Guskjolen

1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

3Department of Physiology, University of Toronto, Toronto, M5S 1A8, Canada.

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Yosuke Niibori

1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

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Hirotaka Shoji

4Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, 470-1192, Japan.

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Koji Ohira

4Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, 470-1192, Japan.

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Blake A. Richards

1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

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Tsuyoshi Miyakawa

4Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, 470-1192, Japan.

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Sheena A. Josselyn

1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

2Institute of Medical Science, University of Toronto, Toronto, M5S 1A8, Canada.

3Department of Physiology, University of Toronto, Toronto, M5S 1A8, Canada.

5Department of Psychology, University of Toronto, Toronto, M5S 3GM, Canada.

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For correspondence: paul.frankland@sickkids.ca sheena.josselyn@sickkids.ca

Paul W. Frankland

1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

2Institute of Medical Science, University of Toronto, Toronto, M5S 1A8, Canada.

3Department of Physiology, University of Toronto, Toronto, M5S 1A8, Canada.

5Department of Psychology, University of Toronto, Toronto, M5S 3GM, Canada.

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For correspondence: paul.frankland@sickkids.ca sheena.josselyn@sickkids.ca

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Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

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