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A pause sequence enriched at translation start sites drives transcription dynamics in vivo

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Science  30 May 2014:
Vol. 344, Issue 6187, pp. 1042-1047
DOI: 10.1126/science.1251871

Article Information

vol. 344 no. 6187 1042-1047

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History: 
  • Received for publication February 6, 2014
  • Accepted for publication April 18, 2014
  • .

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Author Information

  1. Matthew H. Larson1,
  2. Rachel A. Mooney2,
  3. Jason M. Peters3,
  4. Tricia Windgassen2,
  5. Dhananjaya Nayak2,
  6. Carol A. Gross3,
  7. Steven M. Block4,5,
  8. William J. Greenleaf6,*,
  9. Robert Landick2,7,*,
  10. Jonathan S. Weissman1,*
  1. 1Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, California Institute for Quantitative Biosciences, Center for RNA Systems Biology, University of California, San Francisco, San Francisco, CA 94158, USA.
  2. 2Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.
  3. 3Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA.
  4. 4Department of Biological Sciences, Stanford University, Stanford, CA 94025, USA.
  5. 5Department of Applied Physics; Stanford University, Stanford, CA 94025, USA.
  6. 6Department of Genetics, Stanford University, Stanford, CA 94025, USA.
  7. 7Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.
  1. *Corresponding author. E-mail: wjg{at}stanford.edu (W.J.G.); landick{at}biochem.wisc.edu (R.L.); weissman{at}cmp.ucsf.edu (J.S.W.)

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