Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke

A. S. Wahl; W. Omlor; J. C. Rubio; J. L. Chen; H. Zheng; A. Schröter; M. Gullo; O. Weinmann; K. Kobayashi; F. Helmchen; B. Ommer; M. E. Schwab

doi:10.1126/science.1253050

Research Article

Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke

A. S. Wahl¹,²,*,
W. Omlor²,
J. C. Rubio³,
J. L. Chen²,
H. Zheng³,
A. Schröter⁴,
M. Gullo¹,²,
O. Weinmann¹,²,
K. Kobayashi⁵,
F. Helmchen²,
B. Ommer³,
M. E. Schwab¹,²,*

¹Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
²Brain Research Institute, University of Zurich, Zurich, Switzerland.
³Computer Vision Group, Heidelberg Collaboratory for Image Processing and Interdisciplinary Center for Scientific Computing (IWR), University of Heidelberg, Heidelberg, Germany.
⁴Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.
⁵National Institute for Physiological Sciences, National Institute of Natural Sciences Myodaiji, Okazaki, Japan.

↵*Corresponding author. E-mail: schwab{at}hifo.uzh.ch (M.E.S.); wahl{at}hifo.uzh.ch (A.S.W.)

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Science 13 Jun 2014:
Vol. 344, Issue 6189, pp. 1250-1255
DOI: 10.1126/science.1253050

A. S. Wahl

Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.Brain Research Institute, University of Zurich, Zurich, Switzerland.

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For correspondence: schwab@hifo.uzh.ch wahl@hifo.uzh.ch

W. Omlor

Brain Research Institute, University of Zurich, Zurich, Switzerland.

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J. C. Rubio

Computer Vision Group, Heidelberg Collaboratory for Image Processing and Interdisciplinary Center for Scientific Computing (IWR), University of Heidelberg, Heidelberg, Germany.

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J. L. Chen

Brain Research Institute, University of Zurich, Zurich, Switzerland.

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H. Zheng

Computer Vision Group, Heidelberg Collaboratory for Image Processing and Interdisciplinary Center for Scientific Computing (IWR), University of Heidelberg, Heidelberg, Germany.

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A. Schröter

Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.

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M. Gullo

Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.Brain Research Institute, University of Zurich, Zurich, Switzerland.

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O. Weinmann

Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.Brain Research Institute, University of Zurich, Zurich, Switzerland.

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K. Kobayashi

National Institute for Physiological Sciences, National Institute of Natural Sciences Myodaiji, Okazaki, Japan.

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F. Helmchen

Brain Research Institute, University of Zurich, Zurich, Switzerland.

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B. Ommer

Computer Vision Group, Heidelberg Collaboratory for Image Processing and Interdisciplinary Center for Scientific Computing (IWR), University of Heidelberg, Heidelberg, Germany.

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M. E. Schwab

Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.Brain Research Institute, University of Zurich, Zurich, Switzerland.

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For correspondence: schwab@hifo.uzh.ch wahl@hifo.uzh.ch

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Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke

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