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The genetics of Mexico recapitulates Native American substructure and affects biomedical traits

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Science  13 Jun 2014:
Vol. 344, Issue 6189, pp. 1280-1285
DOI: 10.1126/science.1251688

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The population structure of Native Mexicans

The genetics of indigenous Mexicans exhibit substantial geographical structure, some as divergent from each other as are existing populations of Europeans and Asians. By performing genome-wide analyses on Native Mexicans from differing populations, Moreno-Estrada et al. successfully recapitulated the pre-Columbian substructure of Mexico. This ancestral structure is evident among cosmopolitan Mexicans and is correlated with subcontinental origins and medically relevant aspects of lung function. These findings exemplify the importance of understanding the genetic contributions of admixed individuals.

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