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Science  04 Jul 2014:
Vol. 345, Issue 6192, pp. 102
DOI: 10.1126/science.345.6192.102-a

Ready-to-Use Lentivirus

A range of ready-to-use human and mouse lentivirus products is now available for miRNA and anti-miRNA expression (miRNA inhibition). miRNA mainly silence or repress gene expression via binding to the complementary sequences of gene-coding mRNA. Each miRNA can target multiple genes. AMSBIO's range of ready-to-use, anti-miRNA lentivirus (miRNA inhibitors) are produced from the optimally designed anti-miRNA lentivectors. The annealed DNA oligonucleotides hairpin duplex encoding the antisense of a specific miRNA sequence are cloned under a constitutive human U6 promoter or under an optional inducible human H1 promoter. AMSBIO's anti-miRNA lentivector was carefully designed for the highest anti-miRNA expression level with precise promoter transcription position, and to favor the antisense strand for RISC complex processing. Anti-miRNA or miRNA inhibitors are short RNA molecules complementary to the mature miRNA sequence. Anti-miRNA specifically binds to endogenous miRNA and inhibits or down-regulates miRNA activity.

UPLC System

The ACQUITY UPLC M-Class System is an industry-first nano- to microscale UltraPerformance LC (UPLC) system rated for 15,000 psi operation. Its new 15k psi-capable ACQUITY UPLC M-Class Columns tap the potential of sub-2-μm particle technology, yielding faster separations, greater peak capacities, and increased levels of sensitivity. Nano- to microscale LC is defined by flow rates of 200 nL/minute to 100 μL/minute with columns having an internal diameter of up to 1 mm. The advantages include the conservation of sample and solvent, increased sensitivity, and a flow rate compatible with high sensitivity electrospray ionization mass spectrometry. The innovations incorporated into the system are led by its internal low-volume design and newly redesigned fluidics that minimize dispersive and adsorptive losses during a chromatographic separation. The increased pressure envelope enables the system to exploit fully sub-2-μm particles in longer columns—up to 25 cm in length—resulting in faster separations and better resolution of individual chromatographic peaks.

Vial Identification System

Misidentifying and mishandling sample vials can cause lost samples, botched experiments, and costly product recalls. User complaints about manual labeling mostly center around illegible handwriting, smearing from solvents, and general degradation over time. The Virtuoso system is designed to solve these problems by printing clear, indelible, detailed information directly on the vials. The Virtuoso system's software provides automated download of sample lists, on-demand system diagnostics, and emergency sample labeling. Vial identification data can be input using the unit's touchscreen or directly from the lab network. Templates include standard required information, and users can customize them to suit their specific needs, including text, graphics, barcodes, and logos. The images resist conditions found in most labs, including solvents and handling. The vial identification system uses Thermo Scientific Virtuoso Vials for optimal performance, available in a variety of dimensions, glass colors, and closures. The unit's sleeve holds up to 10 vials for autoloading.

Light Scattering Detector

Viscotek SEC-MALS 20 has brought new standards of performance and greater choice in gel permeation/size exclusion chromatography (GPC/SEC) and has extended the family of light scattering detectors for measuring the absolute molecular weight of proteins, macromolecules, and polymers. Molecular weight has an overriding influence on the physical, structural, and chemical properties of polymer, protein, and macromolecular species. Modern GPC/SEC systems use static light scattering detectors for absolute molecular weight, rather than relying on unsuitable, potentially inaccurate external calibration methods. The new Viscotek SEC-MALS 20 is designed to measure absolute molecular weight for a range of macromolecular applications and to supply superior radius of gyration measurements for molecules larger than 10�15 nm. The new Viscotek SEC-MALS 20 has more detectors than any other commercially available MALS system. This increased level of detection, particularly at lower angles, gives the best possible data fit for the extrapolation of molecular weight and size.

Common Tube Rotor

Designed for applications that use common, disposable conical tubes, JA-14.50 rotors extend the applications and flexibility of the Avanti centrifuge series, and can be used in Avanti J-26S, J-30I, and J-E centrifuges. While greater capacity results in higher throughput, the rotors maintain the precision performance offered by products in the Avanti line and are the only high-performance rotors capable of spinning 50, 15, 5, and 1.5 mL conical tubes, and 50, 15, and 10 mL round bottom tubes and bottles at their maximum speeds. Delivering a top speed of 14,000 rpm and rcf of 35,000 x g, JA-14.50 rotors hold up to 16 x 50 mL conical tubes and maximize the number of 50 mL conical tubes that can be processed in a single run. The fixed-angle rotor is intended for general pelleting of cells, bacteria, and food products; separating proteins, viruses, and subcellular fractions; running concentrators and columns; and for phase separation and binding studies.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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