Research Article

Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

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Science  04 Jul 2014:
Vol. 345, Issue 6192, pp. 50-54
DOI: 10.1126/science.1250373

Article Information

vol. 345 no. 6192 50-54

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History: 
  • Received for publication January 3, 2014
  • Accepted for publication June 10, 2014
  • .

Author Information

  1. Lars Iversen1,*,,
  2. Hsiung-Lin Tu1,*,
  3. Wan-Chen Lin1,
  4. Sune M. Christensen1,,
  5. Steven M. Abel2,,
  6. Jeff Iwig3,
  7. Hung-Jen Wu1,§,
  8. Jodi Gureasko3,,
  9. Christopher Rhodes4,
  10. Rebecca S. Petit1,
  11. Scott D. Hansen1,
  12. Peter Thill5,
  13. Cheng-Han Yu6,,
  14. Dimitrios Stamou7,
  15. Arup K. Chakraborty2,5,8,9,10,11,
  16. John Kuriyan1,3,12,
  17. Jay T. Groves1,6,12,13,#
  1. 1Howard Hughes Medical Institute, Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
  2. 2Department of Chemical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  3. 3Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
  4. 4Department of Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720, USA.
  5. 5Department of Chemistry, MIT, Cambridge, MA 02139, USA.
  6. 6Mechanobiology Institute, National University of Singapore, Singapore.
  7. 7Department of Chemistry and Nano-Science Center, University of Copenhagen, Copenhagen, Denmark.
  8. 8Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
  9. 9Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA 02139, USA.
  10. 10Department of Physics, MIT, Cambridge, MA 02139, USA.
  11. 11Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139, USA.
  12. 12Physical Biosciences and Materials Sciences Divisions, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
  13. 13Berkeley Education Alliance for Research in Singapore, 1 Create Way, CREATE tower level 11, University Town, Singapore 138602.
  1. #Corresponding author. E-mail: jtgroves{at}lbl.gov
  1. * These authors contributed equally to this work and are listed in alphabetical order.

  • Present address: Department of Chemistry, University of Copenhagen, Copenhagen, Denmark.

  • Present address: Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN 37996, USA.

  • § Present address: Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA.

  • Present address: Epizyme, 400 Technology Square, Cambridge, MA 02139, USA.

  • Present address: Department of Anatomy, The University of Hong Kong, Hong Kong.

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