Contents
Vol 345, Issue 6193
Special Issue
Strategies against HIV/AIDS
Introduction to special issue
News
- First, do harm reduction
Australia's aggressive efforts to stop HIV's spread via injecting drugs averted a catastrophe.
- The limits of success
Increasing prevalence in Australia's men who have sex with men raises questions about treatment as prevention.
- Prevention, Papua New Guinea style
A community gathers to watch a video about HIV's impact on a local family and meet the star.
- The circumcision conundrum
No clear mechanism explains how removing a foreskin protects men from HIV, but traditional penile cutting in Papua New Guinea may help clarify.
- A consummate insider pushes ideas from outside Indonesia
Sex and drugs rock Health Minister Mboi's reign.
- Malaysia tries to follow Australia's path
A top researcher and advocate pushes for change.
Editorial
Perspective
Review
Contents
This Week in Science
Editorial
Editors' Choice
Podcasts
- Science Podcast: 11 July Show
On this week's show: A sea of plastic bits and a roundup of stories from our daily news site.
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Uncontacted tribe in Brazil emerges from isolation
Anthropologists worry about the threat from novel infections and conflicts with other tribes.
- Medical isotopes confound nuclear test monitoring
Gases from medical isotope plants can mimic the signature of a bomb, but makers say they will cut emissions.
- Conflict erupts over landmark E.U. neuroscience plan
Scientists threaten to boycott the Human Brain Project.
- India plans the grandest of canal networks
Nationwide water transfer scheme could aid farming, but critics fear ecological havoc.
- RIP for a key Homo species?
Researchers consider killing off a claimed common ancestor of Neandertals and modern humans.
Feature
- Monkey fever unbound
The spread of an emerging disease from its forest stronghold is sounding alarm bells in India.
Working Life
Letters
Books et al.
Perspectives
- Taking the pulse of ocean microbes
Gene expression patterns of open-ocean microbes are tightly coupled.
- A fitness bottleneck in HIV-1 transmission
A successful infection is determined in part by how close a viral genome is to an ideal sequence.
- Low-energy electron diffraction at ultrafast speeds
Thermally induced structural changes in a thin polymer film could be resolved with picosecond time resolution.
- An optical twist for triplet superconductors
Optical measurements may help reveal the secrets of exotic superconductivity and manipulate the pair condensate.
- A flipping cell wall ferry
How bacteria “flip” carbohydrate precursors across the cytoplasmic membrane.
- Hepatitis C can be cured globally, but at what cost?
New drugs to cure hepatitis C should be made available at low costs in developing countries
- Fishing for peroxidase protons
Where are the protons in heme protein catalysis?
- Persistence by proliferation?
Latently HIV-infected cells driven to proliferate may raise a further challenge for eradication strategies.
- Microplastics in the seas
Concern is rising about widespread contamination of the marine environment by microplastics.
Research Articles
- Selection bias at the heterosexual HIV-1 transmission bottleneck
An analysis of discordant couples reveals that transmitted HIV-1 viruses are typically the most evolutionarily fit.
- Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
Where HIV integrates into the host genome contributes to viral persistence and the expansion of infected cells.
Reports
- Ionospheric control of magnetotail reconnection
Asymmetric plasma flows on the night side of Earth are regulated by magnetosphere-ionosphere coupling.
- Fermi arcs in a doped pseudospin-1/2 Heisenberg antiferromagnet
Some of the phenomenology of cuprate superconductors is recreated in strontium iridate surface-doped with potassium.
- Observation of broken time-reversal symmetry in the heavy-fermion superconductor UPt3
Optical measurements elucidate the nature of superconductivity in an exotic compound.
- Neutron cryo-crystallography captures the protonation state of ferryl heme in a peroxidase
The sensitivity of neutron scattering to proton locations clarifies the acid/base chemistry of a biochemical oxidation.
- Assessing the reliability of calculated catalytic ammonia synthesis rates
A method for estimating the uncertainty of calculated properties in density functional theory is introduced.
- Ultrafast low-energy electron diffraction in transmission resolves polymer/graphene superstructure dynamics
Time-resolved low-energy electron diffraction resolves picosecond structural dynamics in a polymer-graphene bilayer.
- Supershear rupture in a Mw 6.7 aftershock of the 2013 Sea of Okhotsk earthquake
Earthquakes that occur hundreds of kilometers below the surface may have more than one rupture mechanism.
- Multispecies diel transcriptional oscillations in open ocean heterotrophic bacterial assemblages
Multispecies’ daily waves of gene transcription are observed in open ocean microplankton.
- Harnessing naturally occurring data to measure the response of spending to income
How do theoretical predictions of individual fiscal behaviors match up against real-world, real-time data?
- Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility
Mutational analysis of tumor cells isolated from the blood of cancer patients may help optimize treatment selection.
- MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis
The identity of the final essential component of the bacterial peptidoglycan biogenesis pathway is elucidated.
- A Doppler effect in embryonic pattern formation
Genetic oscillations, their changing spatial pattern, and tissue shortening direct the rhythm of sequential body segmentation.
Technical Comments
From the AAAS Office of Publishing and Member Services
